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Genetic fusions favor tumorigenesis through degron loss in oncogenes

Fusions involving known oncogenes often retain functional domains and are "in-frame," supporting their role in cancer, as noted in the Nature Communications study . 24336.rar

The study highlights how losing a degron (a protein degradation signal) stabilizes the resulting fusion protein. Genetic fusions favor tumorigenesis through degron loss in

If you can tell me where you saw the file "24336.rar" or provide more context on its content, I can try to give you a more specific report. " supporting their role in cancer

9,624 tumor samples from TCGA, investigating degron loss (a mechanism that stabilizes proteins, encouraging cancer growth). Key Findings: