: For the first time, white matter characteristics are part of the formal criteria. A diagnosis of probable CAA can now be made with just one lobar hemorrhagic lesion if accompanied by either:
: Specific patterns of white matter damage. Clinical Significance : For the first time, white matter characteristics
: The minimum age for applying the criteria has been lowered from 55 to 50 years . : For the first time
The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria : For the first time, white matter characteristics