Episode 22: Resignation May 2026

: A 19-year-old college student and karate practitioner suddenly coughs up blood during a workout. After numerous tests fail to explain her declining health, it is revealed she attempted suicide by ingesting a specific cleaner, which caused a bacterial infection.

: House suspects Dr. Wilson is depressed and sluggish. In a classic "House" move, he spikes Wilson’s coffee with amphetamines (speed) to "help" him, leading to Wilson being hyperactive and jittery throughout the episode. Cast and Credits Director : Martha Mitchell. Writer : Pamela Davis. Guest Star : Piper Perabo plays the patient, Honey. Where to Watch Episode 22: Resignation

is the 22nd episode of the third season of House, M.D. (Season 3, Episode 22). It originally aired on May 8, 2007, on FOX. Episode Overview : A 19-year-old college student and karate practitioner

: The episode’s primary B-plot centers on Dr. Eric Foreman’s decision to resign from House's team. He fears that he is becoming too much like House—cold, cynical, and willing to cross ethical lines. Wilson is depressed and sluggish