: A "syphilis train" starts with Alex and spreads to Olivia and George.

Meredith Grey spent the day feeling like her relationship with Derek Shepherd was finally on solid ground. They had survived the initial awkwardness of their secret romance and the pressures of the internship. But at Seattle Grace Hospital, peace was always temporary. A syphilis outbreak had swept through the staff, forcing the Chief to hold a mandatory—and humiliating—meeting about sexual health. George O’Malley was the most public victim of the "syphilis train," having contracted it from Olivia, the nurse who had caught it from Alex Karev.

Derek froze, his face draining of color. "Addison. What are you doing here?"

Watch a recap and review of the intense season 1 finale where secrets are finally brought to light:

The woman turned her gaze to Meredith, her eyes sharp. "And you must be the woman who's been sleeping with my husband."