It tethers vesicles to the plasma membrane, facilitating sound encoding.
The protein utilizes C2 domains to bridge synaptic vesicles to the plasma membrane (plasma membrane being the "target membrane"). tm,cc,jp
Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power It tethers vesicles to the plasma membrane, facilitating
This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds. tm,cc,jp
Structure and function of otoferlin, a synaptic protein of ... - PMC
ions are bound per domain, with specific significance for the .
The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.